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Aside from restricting the vaccine to postexposure prophylaxis (PEP), other principles in the draft document include centralization of national-state communications, mandatory consultation with knowledgeable public health officials before use of the vaccine, and renewed education and outreach for key medical providers regarding what constitutes a true exposure.
The cost of postexposure prophylaxis is approximately $500 for the two-drug therapy and $1,000 for the three-drug therapy in addition to laboratory costs, which can total about $300.
Routine vaccination of patients every 10 years is important to prevent tetanus, particularly in settings where patients do not seek medical care following an injury, where no injury is evident to the patient, or where appropriate postexposure prophylaxis is not provided following an injury.
We tabulated the number of persons exposed in each subdistrict, number of persons who received postexposure prophylaxis, and reasons for doing so.
The findings from the query enabled health department staff to give postexposure prophylaxis to 36 persons identified as close contacts.
The state health department decided to administer rabies postexposure prophylaxis (PEP) to selected persons who had consumed milk from the Swan Bros.
In addition, the center offers advice on occupational exposure to HIV via the PEPline, a clinicians' postexposure prophylaxis hotline, at 888-448-4911.
Although rabies is preventable, a lack of accurate data on the burden of disease, inadequate rabies diagnostic laboratory capacity, and poor access to rabies vaccine for postexposure prophylaxis has delayed progress towards regional goals for human rabies elimination.
Although <10 human cases have been diagnosed annually since 1990 (2) in the United States, potential exposure incidents and rabies postexposure prophylaxis (PEP) of humans are not rare.
Since that time, data from studies on nonoccupational postexposure prophylaxis (nPEP) have accumulated, and the guidelines have been updated (MMWR Recomm.
Clinicians may consider use of postexposure prophylaxis among profoundly immunocompromised patients on an individual basis.
Although the efficacy of oseltamivir has not been extensively assessed in the elderly, some observational and experimental studies suggest beneficial effects of both continuous and postexposure prophylaxis in containing outbreaks and reducing the number of severe complications among nursing home residents (2,7-10).