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Mati said the Evolute platform includes features for retaining the punctal plug within the nasolacrimal system of the eye during drug elution and sustained release formulations currently in development for the treatment of post-operative pain and inflammation.
Punctal plugs that block tear drainage channels can help conserve tears for dry eye suffers who get little or no relief from artificial tears.
The Company recently announced that results from two Phase II clinical studies, PPL GLAU 12 and PPL GLAU 13, demonstrated positive trends (with statistically and clinically significant findings) on the efficacy and safety of the Latanoprost Punctal Plug Delivery System (L-PPDS) in subjects with ocular hypertension (OH) and open-angle glaucoma (OAG).
The patent, which expires in 2028, claims a method of providing a sustained drug release to an eye using a proprietary punctal plug design placed in the punctum (tear duct) over the treatment period.
Punctal Plug Drug Delivery System NicOx/Pfizer's Glaucoma Drug Alcon's TRAVATANZ[TM] Approval in Japan Lexicon Pharmaceuticals Identifies New Drug Candidate Othera Pharmaceuticals Files Investigational New Drug
M2 EQUITYBITES-April 5, 2013-QLT Inc reports divestiture of punctal plug technology to Mati Therapeutics Inc(C)2013 M2 COMMUNICATIONS http://www.
30 August 2011 - Canadian ocular products developer QLT Inc (TSX:QLT) announced yesterday positive results of its Phase II clinical study on the efficacy and safety of the Latanoprost Punctal Plug Delivery System (LPPDS) in subjects with ocular hypertension (OH) and open-angle glaucoma (OAG).
Punctal Plug: In cases of moderate to severe dry eye, tears can be conserved by placement of a temporary or permanent punctal plug into the channel at the inner corner of the eyelid where tears drain into the nose and the back of the throat.