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Related to Recklinghausen's disease: type 1 neurofibromatosis
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Personal and familial history was negative for von Recklinghausen's disease.
This is more likely to occur when there are multiple tumors associated with Von Recklinghausen's disease, where the incidence of malignancy is approximately 15%.
Diseases that cause enlargement of the tongue from multiple lesions include Down syndrome and rare conditions such as hypothyroidism, Beckwith-Wiedemann syndrome, the mucopolysaccharidoses (MPS), multiple endocrine neoplasia syndrome type 2B (MEN 2B) and neurofibromatosis (von Recklinghausen's disease of the skin).