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Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma.
3-q32 protein, acidic, cysteine-rich (osteonectin) RPRM Reprimo, TP53- Hypermethylation 2q23.
A routine screening procedure that might be developed from testing for a methylated Reprimo gene would be vital.
A gene called Reprimo is shut down in several cancers but rarely in healthy cells, a new study shows.
Reprimo is poised to take its place on the growing list of genes that normally keep cell growth in cheek but fail in cancer.
His team reports that a cell can stifle Reprimo activity by attaching chemical methyl groups to a DNA on-off switch, called a promoter, that's near the gene.
Reprimo was also methylated in 40 percent of esophageal cancer samples tested and in one-third of leukemia and breast cancer samples.
To confirm that methylation was responsible for silencing Reprimo in the cancerous cells, the researchers treated some of the cells with a demethylating agent.
On the other hand, methylated Reprimo showed up in one-fourth of all colon polyps tested.
The findings suggest that aberrant methylation of the Reprimo promoter is among the earliest events in the origin of some cancers, Gazdar says.