The mortality rate in the group treated with reteplase
Keywords: Escherichia coli, Recombinant proteins, Reteplase
, Tissue plasminogen activator
Plasmids were digested with Nco, and BamH, restriction enzymes to obtain reteplase
Connors suggested the lytic capabilities for intraarterial thrombolysis with reteplase
and alteplase are about equal, and the optimal infusion concentrations should be about 1 U reteplase
/100 cc normal saline infused at 0.
has been used in thrombosed hemodialysis access grafts (Falk et al.
is reconstituted only in sterile water for injection, USP (without preservatives) to achieve a final concentration of 1 U/1 ml and remains biologically active for at least 8 hours (Centocor, Inc.
But the value of adding reviparin or a similar agent remains in doubt when patients are treated with the fibrin-specific drugs typically used for thrombolysis in the United States, such as alteplase (tissue plasminogen activator), reteplase
, and tenecteplase.
BRAVE was an open-label multicenter trial involving 253 German acute MI patients randomized to half-dose reteplase
plus full-dose abciximab or to abciximab alone during the interval between diagnosis and transfer to a cardiac catheterization lab for PCI.
Published reports to date exclusively used streptokinase, urokinase, reteplase
, or recombinant tissue plasminogen activator (t-PA).
All of these agents are given intravenously Alteplase (Activase), reteplase
(Retavase), and tenecteplase (TNKase), produced with recombinant DNA technology are not teratogenic in animals and are all rated C.
Results of the Early Reteplase
Thrombolysis in Myocardial Infarction-19 (ER TIMI-19) trial, reported by Dr.
One of the new options, half-dose reteplase
plus heparin and a half dose of abciximab, an antiplatelet drug, looked especially good for younger patients and those with larger infarctions, Dr.