The two-dopamine receptors are principally responsible for the activation or inhibition of adenyl cyclase, which facilitates second messenger
concepts in bacterial second messenger
signaling and has motivated the search for previously
Now scientists at Columbia University in New York City report a newly identified class of second messengers
, which may play a double role in carrying signals both within and between cells.
Based on these early results, we believe that CT-2576 and other compounds of this class that can suppress the generation of this specific species of phosphatidic acid should be of therapeutic interest for delaying or preventing the onset of AIDS and certain other viral diseases in HIV-infected patients with greater specificity and safety than pharmaceuticals which inhibit normal second messenger
Therapeutics based on such compounds could offer greater specificity and safety than pharmaceuticals which inhibit normal second messenger
The formal validation studies conducted jointly by Axiom and Cadus established a large data set demonstrating the feasibility of HT-PS for measuring multiple intracellular second messenger
pathways, such as calcium mobilization and changes in membrane potential across a variety of human and rodent cell lines.
Subsequently, Sutcliffe has focused his research in the area of the molecular nature of neural function, with interests in synaptic signal and second messenger
action, especially in regard to memory and the involvement of serotonin in circadian rhythms, and the genetic basis of retinitis pigmentosa, using molecular, genomic and transgenic technologies.
Material is arranged in sections on biophysical chemistry, metabolism, second messengers
, and ultrastructure; membrane potential, transport physiology, pumps, and exchangers; membrane excitability and ion channels; synaptic transmission and sensory transduction; and muscle and other contractile systems.
In particular, it has been recently demonstrated that carnosine is a potent and selective scavenger of alpha,beta-unsaturated aldehydes, typical by-products of membrane lipids peroxidation and considered second messengers
of the oxidative stress, and inhibits aldehyde-induced protein-protein and DNA-protein cross-linking in neurodegenerative disorders such as Alzheimer's disease, in cardiovascular ischemic damage, in inflammatory diseases.
The anthology represents a considerable update and expansion of the 1999 Lipid Second Messengers
2] and generation of two key intracellular second messengers
The pathogen also activates host PLC upon bacterial contact, leading to the production of two second messengers
, which further initiate signaling events (42).