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Current laboratory and clinical evidence suggests that aging results in: (1) diverse and nonuniform declines in the morphology and physiological function of the various sensory structures examined, (2) preferential loss of distal large myelinated sensory fibers and receptors, and (3) impaired distal lower-extremity proprioception, vibration and discriminative touch, and balance. Jordt has found that some of those receptors are also activated by environmental irritants, and that the response is likely to involve the ion channel TRPA1, which is expressed exclusively in sensory fibers that are also sensitive to capsaicin, an irritant derived from chili peppers. The messages in sensory fibers and their interpretation. |
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