Those interested in learning more about Icagen's sodium channel
portfolio and its application to specific drug discovery problems are invited to attend the company's webinar, "Voltage Dependent Sodium Channel
Drug Discovery Screening, Lead Optimization, and Candidate Selection Using Icagen's Integrated Service Platform," on October 7, 2015 from 11:00 am - 12:00 pm Eastern.
Slow Inactivation in Voltage-Gated Sodium Channels
According to the researchers of Duke University, the new antibody works by targeting the voltage-sensitive sodium channels
in the cell membrane of neurons.
Main mechanism of action is GABA and sodium channels
These proteins, called sodium channels
, operate tiny gates to control the flow of sodium into the cell.
Stretch modulates amiloride sensitivity and cation selectivity of sodium channels
in human B lymphocytes.
Shehata MF Regulation of the epithelial sodium channel
[ENaC] in kidneys of salt-sensitive Dahl rats: insights on alternative splicing.
Serge Sicouri presented a poster demonstrating the antiarrhythmic effects of a new drug, GS 458967, being developed by Gilead Sciences to prevent sudden cardiac death syndromes via highly-selective late sodium channel
In suspected patients, induction especially by sodium channel
blockers is helpful in the diagnosis.
Mutations of the SCN5A gene responsible for the alpha subunit of the cardiac sodium channel
have been implicated in approximately 20 to 25% of individuals (3).
Kay Wagoner, CEO of Icagen, stated, "We are very pleased to report positive progress in our sodium channel
pain collaboration with Pfizer in which compounds are now being advanced into first-in-man studies.
Waxman's research has shown even more potent ramifications for the role of ion channel dysfunction in MS, by demonstrating a strong association between sodium channel
abnormalities and nerve fiber damage in mice with the MS-like disorder EAE.