Effects of rhinovirus infection on the expression and function of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel
in human nasal mucosa.
Researchers studied the sodium channel
of 584 people with IBS and 1,380 control subjects.
The firing of action potentials depends on the highly coordinated opening and closing of tiny gates called sodium channels
that are present within the axon membrane.
SCN4A -associated disorders include hyperkalemic periodic paralysis (hyperPP, OMIM: 170500), hypokalemic periodic paralysis Type 2 (OMIM: 613345), paramyotonia congenita (PMC, OMIM: 168300), sodium channel
myotonias (SCM, OMIM: 608390), and congenital myasthenic syndrome (OMIM: 614198).
The sodium channel
route has experienced roadblocks, however.
Comparing the effect of potassium and of sodium channel
block, one can see that they have much different influences on temporal coherence of the network.
Nerve cells talk to each other by means of these electrical impulses, and the sudden activity of extra sodium channels
can cause a nerve to fire machine-gun-like bursts "spontaneously, even when there are no threatening stimuli," explains Stephen Waxman, a professor of neurology at Yale University who directs the Center for Neuroscience and Regeneration Research at a Veterans Affairs hospital in Connecticut.
Abbreviations ENaC: Epithelial sodium channel
AMPK: AMP-activated protein kinase eNOS: Endothelial nitric oxide synthase NO: Nitric oxide HUVEC: Human umbilical vein endothelial cells [P.
NF-xB-dependent transcriptional regulation of the cardiac scn5a sodium channel
by angiotensin II," The American Journal of Physiology--Cell Physiology, vol.
Another emerging area of personalized pain management is the screening of individuals with neuropathic pain for mutations in sodium channel
Hydralazine, a vasodilator for hypertension, and procainamide, an antiarrhythmic sodium channel
blocker, inhibit DNA methylation and thereby affect the epigenome.
So, for example, if your loved one fails a medicine in the Sodium Channel
family, your provider might switch them to a GABA family medicine or a Mixed Neurotransmitter family, since the Sodium Channel
one did not work.