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A total of 12 patients were treated with a single, intratumoural injection of REOLYSIN(R) at dosages of 1x10(7), 1x10(8), and 1x10(9) TCID50 in a delivery volume of 0.
Similar reductions in log10 TCID50 viral titer were observed over the first 48 hours in the two treatment groups, -1.
Animals were vaccinated on days 0 and 21 and challenged on day 49 with 105 TCID50 (50% Tissue Culture Infective Dose*) of H5N1/ A/ Indonesia/5/05 (clade 2).