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As seen in a previous completed clinical trial in women, there was no evidence of absorption of the active ingredient of VivaGel(TM), SPL7013, into the blood after topical application. We therefore studied whether topical application of zinc to TB skin test sites would augment test results in Lima, Peru, a TB-endemic area in which false-negative skin-test results are frequent (1). After the topical application of a vasoconstricting agent, visible disease is excised with an eye toward minimizing complications, such as vocal fold scarring, glottic webs, and stenosis of the supra- or subglottic airway. |
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