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The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives.
Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme.
Intoplicine (RP 60475) and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities.
Previous papersdemonstrated that Camptothecins have anticancer activities, scientists mentioned antineoplatic and topoisomerase I inhibitor activity of Camptothecins (12).
77 and it was indicated that all of them were potent anticancer agents that definitely were antineoplastics, topoisomerase I inhibitor and DNA intercatalor agents.
Topotecan--A novel topoisomerase I inhibitor: pharmacology and clinical experience.
The compounds we have identified are likely to succeed as the basis of a drug because they are the first known compounds to successfully inhibit the topoisomerase I enzyme.
Topoisomerase I is most vulnerable in cells at a stage of the cell cycle known as the "S" phase.
NeXstar scientists produced a liposomal formulation of lurtotecan, NX 211, designed to overcome many of the disadvantages of other topoisomerase I inhibitors.
Both involved a novel approach to the administration and use of camptothecin (CPT), the parent compound in a family of agents that inhibit DNA replication by binding the topoisomerase I enzyme.
NASDAQ:MATX) scientists and their colleagues at the University of Virginia and the National Cancer Institute (NCI) presented findings from studies evaluating intratumoral delivery of topoisomerase I and topoisomerase II inhibitors in Matrix's proprietary anhydrous vehicle systems.
Topoisomerase I and II affect DNA binding, replication and repair and are the subject of significant interest in the cancer research community.