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These isolated compounds show the greatest MMP inhibitory effect of MMPs at minimal toxic dose levels.
Four years ago, scientists reported that in rats, large doses of vitamin A transform minimally toxic doses of carbon tetrachloride into a potent liver poison.
8), and its therapeutic dose may be close to, if not overlapping, its toxic dose, Turner notes.
The truth is a child who weighs about 50lbs would have to eat over 500 poinsettia leaves to reach a potentially toxic dose from a poinsettia plant.
Our estimate is that as many as 10 percent of the children in the American Southwest have potentially been exposed to a toxic dose [of lead]," Trotter reported this month at a conference on advances in lead research, convened by the National Institute of Environmental Health Sciences in Research Triangle Park, N.
Overexposure may result despite careful selection of patients and adjustment of dose, both because the effective dose must often be close to a toxic dose and because patients vary in their capacity to break down 5-FU and eliminate it from the body.
However, with a lot of herbs, the toxic dose isn't known simply because the research hasn't been done.
Cough medicines traditionally contain more than one ingredient and if a parent doubled up with another product, the toxic dose of one of them could be given accidentally to a baby.
Specific Agents and Treatments, which features a thorough discussion of specific drug overdoses and poisons, including toxic dose, clinical presentation, diagnosis, and specific treatment associated with each substance.
He added: "There is very little difference between the effective dose and the toxic dose of most anaesthetics.