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Common to all Burkitt lymphomas, endemic or sporadic, are distinctive chromosomal translocations that reactivate expression of the c-myc protooncogene and comprise the primary oncogenic mechanism. Some convincing data show that ALL can arise in utero because characteristic chromosome translocations that generate chimeric fusion genes unique for each patient's leukemic clone are found at birth (Greaves 2002); therefore, the pregnancy and periconceptional periods are exposure windows of primary interest to study risk factors that could be involved in childhood ALL. We should be very worried," he says, "because several diseases or pathogens have been linked to the wildlife and bushmeat trade, and to wildlife translocations worldwide. |
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