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This increase results in a higher volume of distribution for most drugs. These variables are bioavailability, volume of distribution (Vd), and clearance. Usefulness of the software algorithm was assessed based on its ability to eliminate sub-optimally positioned catheters that would likely limit drug distribution due to leakage into cerebrospinal fluid (CSF) spaces, and on the match of the volume of distribution of the infusate as shown by SPECT and simulation. |
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