Una mutacion del gen de amelogenina puede causar defectos hereditarios del esmalte dental conocidos como
amelogenesis imperfecta (AI).
Developmental defects of the enamel are caused by various etiological factors, such as
amelogenesis imperfecta, overexposure to fluoride along the mineralization of the enamel, different disorders, or trauma.
Zoupa et al., "Enamel-free teeth: Tbx1 deletion affects
amelogenesis in rodent incisors," Developmental Biology, vol.
[5] During
amelogenesis, the enamel changes from a protein-rich soft tissue to a hard tissue entirely devoid of protein, and this change is dependent on certain molecular and cellular activities, which in turn, depends on the genes mentioned above.
The frequency of other anomalies was as follows: molar-incisor hypomineralization 0.25%, turner hypoplasia 0.1%, fluorosis 0.1%, odontoma 0.1%, fusion 0.09%, gemination 0.06%,
amelogenesis imperfecta 0.05%, dens invaginatus 0.03%, talon cusp 0.02%, taurodontism 0.02%, macrodontia 0.02%, dentinogenesis imperfecta 0.02%, dilaceration 0.02%, ectopic eruption 0.01% and microdontia 0.01%.
Reduced hydrolysis of amelogenin may result in X-linked
amelogenesis imperfecta.
Conservative restoration with resin composites of a case of
amelogenesis imperfecta.
Among the topics are the slim concept for ideal peri-implant soft tissues, the biodigital alveolar model: an alternative for a predictable esthetic outcome with ultra-thin porcelain veneers, the concept of an angulated screw channel system, balancing surgical and prosthetic procedures to restore the severely resorbed esthetic zone, and CAD/CAM-guided patterns for full-mouth reconstruction using lithium disilicate pressed ceramics in a patient with
amelogenesis imperfecta.
Esta variante se caracteriza por la presencia de celulas granulares dentro del islote ameloblastico y corresponden a celulas epiteliales transformadas con un citoplasma amplio, ocupado por granulos que se tinen intensamente con la eosina y que se describen normalmente durante el proceso de
amelogenesis (figura 1).