Antigen-presenting cells serve as a bridge between the innate and the adaptive systems, with their specific ability to display a foreign antigen through MHC complex to T cells which then induce the adaptive immune response.
CCR7 and L-selectin (CD62L) homing receptors mediate the migration of Tregs from the thymus to the paracortical regions of draining lymph nodes through HEVs, where they make contact with
antigen-presenting cells [49, 50].
Dendritic cells (DCs) are important
antigen-presenting cells and play an important role in immune response by linking the innate and adaptive immunity [11, 12].
Apexigen's APX005M is a novel, humanized monoclonal CD40 agonist antibody that stimulates the anti-tumor immune response in the tumor microenvironment through activation of
antigen-presenting cells of the immune system.
Maturation of naive [CD4.sup.+] T cells to effector [CD4.sup.+] T cells involves costimulation between major histocompatibility complex II (MHC class II) which are only present on
antigen-presenting cells (B cells, macrophages, and dendritic cells) and T cell receptor on the naive [Cd4.sup.+] T cells (Figure 1) [28, 29].
ADXS-HPV is designed to infect
antigen-presenting cells and direct them to generate a powerful, cellular immune response to HPV E7, concluded the company.
The researchers found that one TLR, known as TLR8, triggered a strong immune response in
antigen-presenting cells, which are crucial for vaccine responses.
CTLA4Ig binds to CD80 and CD86 on
antigen-presenting cells, blocking the engagement of CD28 on T cells and preventing T-cell activation.
If the part of HIV that is similar to the
antigen-presenting cells were used as a vaccine, the antibodies generated against the vaccine material would also be capable of attacking the
antigen-presenting cells themselves.
APX005M, a novel, humanized monoclonal antibody that stimulates the anti-tumor immune response in the tumor microenvironment through
antigen-presenting cells of the immune system, is engineered to selectively activate CD40 in tumor tissues, rather than broadly in the bloodstream like other CD40 agonists.
Dendritic cells, which can activate the naive T cells, are the most powerful professional
antigen-presenting cells. The differentiation and development of DCs experiences immature and mature stages.