Its higher values are expected as the direct consequence of the revealed delta cell hyperplasia.
Since the glucose-stimulation index for SST in vitro increased with age of GK rats, being nearly constant in non-diabetic controls, whereas the glucose-stimulation index for insulin rapidly declined with age in both diabetic GK rats and Wistar controls, this clearly reflects new relationships set by the delta cell hyperplasia.
Jones, "Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin," Diabetologia, vol.