Radionuclide scans best demonstrate
Kupffer cell activity.
In the perivenular areas,
Kupffer cells containing ceroid pigments indicative of prior cellular injury and cell turnover are noted.
Yilmaz, "Hepatitis associated with aplastic anemia: do CD8(+)
Kupffer cells have a role in the pathogenesis?" Digestive Diseases and Sciences, vol.
Caption: FIGURE 1: Liver biopsy demonstrating increased iron content in hepatocytes and
Kupffer cells.
Frossard, "Neutrophil depletion-but not prevention of
Kupffer cell activation-decreases the severity of cerulein-induced acute pancreatitis," World Journal of Gastroenterology, vol.
Immunostaining of
Kupffer cells in the liver and foam cells in the liver and the hepatic lymph node for MAC 387 antibody proved that these cells are macrophages.
They identified
Kupffer cells as sources of IL-1[beta] [8].