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Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model.

Diabetes Mellitus With Concurrent Cerebellar Degeneration and Necrosis in a Domestic Goose (Anser anser domesticus)

In a 2012 mouse study, Sahin and colleagues knocked out a TSC gene (Tsc1) in Purkinje cells and found social deficits and repetitive behaviors in the mice, together with abnormalities in the cells.

Lab-Grown Human Cerebellar Cells Enable Study Of Autism

Keywords: Electromagnetic field (EMF), Fourth generation (4G) mobile phones, Purkinje cell layer, Rats, Second generation (2G), Third generation (3G) mobile phones.

EFFECT OF ELECTROMAGNETIC FIELD FROM 2G, 3G AND 4G MOBILE PHONES ON THE ORGANIZATION OF PURKINJE CELL LAYER OF RAT CEREBELLUM

A variety of studies have shown that [alpha]-synuclein accumulates in Purkinje cells during various neurodegenerative diseases like PD and LBD [20, 21].

Accumulation of [alpha]-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers

During wrist movement, Purkinje cells (PCs) with somatosensory receptive fields (RFs) in the distal arm are strongly suppressed before movement onset, while DNs with the same RFs show concurrent bursts of activity (disinhibitory control on DNs).

Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias

Most of the Purkinje cells in cerebellar cortex appeared deformed and shrunken loosing their characteristic pyriform shape after two week .

Study the chronic effect of Aspartame on some neurotransmitters content and histological structure of cerebellar cortex in male albino rats

The most reasonable mechanism is a local hypertrophy of granular cell neurons after migrating more or less completely from the subpial layer, as a compensatory response following degeneration of other neurons or of purkinje cells. Another postulate suggested that the localized disappearance of purkinje cells is secondary to tissue compression due to hypertrophy of granular cell neurons.

Lhermitte-Duclos disease-intraoperative cytological findings of a rare entity

Purkinje cell deficits in nonhuman primates following weekly exposure to ethanol during gestation.

Utilization of magnetic resonance imaging in research involving animal models of fetal alcohol spectrum disorders

The objective of this study was to evaluate the effects of a low dose (1/5 DL50) of cypermethrin on the cerebellar cortex, focusing on the density of the Purkinje cell population and the expression of apoptotic (Apaf-1) and proliferation (Ki67) biomarkers, as regulators of cellular proliferation processes, through the route of caspases and cell cycle regulatory factors, respectively.

Evaluation of the effects on the cerebellar cortex of CF-1 mice exposed to a single dose of cypermethrin/Evaluacion de los efectos de una dosis unica de cipermetrina en la corteza cerebelar de ratones CF-1/Avaliacao dos efeitos de uma dose unica de cipermetrina no cortex cerebelar de ratos CF-1

Unlike the cerebellar granule cells, purkinje cells are all generated before birth on E13 to E16, (13) and Purkinje cell dendritic outgrowth and synaptogenesis occur during postnatal three weeks.

Stereological estimation of granule cell number and Purkinje cell volume in the cerebellum of noise-exposed young rat