The primary
end points included cardiac death and reinfarction.
Although there has been no consistent evidence of a MeHg-PUFA statistical interaction, such interactions may ultimately be present for one or more
end points. If statistical interaction occurs, the relationship shown in Figure 3 becomes more complicated, but interaction can still be addressed in the approach we outline here.
It is only by realising therapy's uniqueness that society, physiotherapists, and patients will resolve the problems of finding its acceptable
end point.
That discussion will include complete analysis of the data including secondary
end points.
That discussion will include complete analysis of the data, including secondary
end points.'
During each week of treatment in both trials, the proportion of patients meeting the primary
end point was significantly greater for both doses of linaclotide compared with placebo.
Major Finding: During at least 9 of the 12 study weeks, 21.2% and 19.4% of patients on 145 mcg and 290 mcg of linaclotide, respectively, achieved the primary
end point of three or more complete spontaneous bowel movements per week plus an increase of one or more complete spontaneous bowel movements per week over baseline.
In a second study, which enrolled 164 patients treated with AZLI or placebo three times a day for 28 days, the primary
end point was the change from day 0 to 28 in clinical symptoms, as assessed by the respiratory scores of a CF symptom questionnaire.
One key challenge for the enterprise in achieving a total security system is to realise that the
end point must now be considered a core network component.
The analyses used changes in either the Mania Rating Scale or the Young Mania Rating Scale as
end points. Most of the studies used 21-day
end points, although one used a 28-day
end point and two used 28-day and 42-day
end points.
The ideal
end point for a study assessing DeLee suction would be meconium aspiration syndrome, since this is the disorder that DeLee suction is designed to prevent.