Morphological features of Sham-operated, myocardial infarction (MI), and MI+ghrelin-treated Rats No Aspects Sham-operated control Rats Atrionatriunetic factor Aggregations of small electron dense granules 1 (ANF) granules occumulated in the central parts of cell close to nucleus and between plasma membrane and peripheral myofibrils Intercalated discs Longitudinal segments running parallel to the 2 myofilaments * Fascia adherence Intact * Desmosomes Intact *
gap junctions Intact Myocardial cells Noimal architecture 3 * Myofibrils Preserved sarcomeres * Z and H bands Clear bands (Z and H).
Having demonstrated that a siRNA against Cx43 is able to block cell-to-cell communication via
gap junctions, we next evaluated the effect of this siRNA on CFTR expression and function.
Spinella et al., "Cloning of a new
gap junction gene (Cx36) highly expressed in mammalian brain neurons," European Journal of Neuroscience, vol.
Mutation analysis of
gap junction protein beta 1 and genotype-phenotype correlation in X-linked Charcot-Marie-Tooth disease in Chinese patients.
(2009) The diverse functional roles and regulation of neuronal
gap junctions in the retina.
The mRNA levels of Cx43 and Cx45 are the important factors involved in
gap junction pathway.
Also, as shown by previous studies, ischaemic reperfusion injury causes rapid dephosphorylation of hexameric structure on cardiomyocyte membrane
gap junctions of cardiomyocytes and leads the dominant form of Cx43 degradation within first few hours.
The report provides comprehensive information on the Connexin (
Gap Junction Protein) , targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Three-dimensional structure of a recombinant
gap junction membrane channel.
Structure of the
gap junction channel and its implications for its biological functions.