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MicroRNAs (miRNAs) are small noncoding ribonucleic acids (RNAs) that modulate gene activity and are aberrantly expressed in cancer.
An aberrantly activated WNT pathway could also play a role in establishing and maintaining cancer stem cells within tumours.
The downregulation of pathologically relevant genes that are aberrantly expressed in a given disease will offer novel therapeutic approaches.
Pharmaceutical intervention of the aberrantly expressed adrenal receptors in AIMAH has been attempted in only a few cases with conflicting results.
Since we have shown that many endometrial genes are aberrantly expressed in the uterine endometrium of pigs carrying SCNT-derived conceptuses (Ka et al.
In this context, it is interesting to note that disruption of the DGCR8 locus is associated with mental retardation and that DGCR8 deletion interferes with the maturation of embryonic stem cells, causing them to aberrantly retain their ability to differentiate into different cell types (i.
Rhodoxanthin was recently found in the orange tail tips of aberrantly colored Cedar Waxwings in eastern North America (Hudon and Brush 1989), and suspected in the origin of aberrant orange plumage colors in other songbirds (Mulvihill et al.
Cilengitide is thought to target certain integrins over-expressed or aberrantly expressed in many cancers that are involved in tumor cell growth and the formation of new tumor-related blood vessels in the tumor microenvironment.
Beyond their evocation of this art-historical hero, the paintings' style also recalls the verism of Neue Sachlichkeit (New Objectivity), with its freakish exaggerations--for example, the work of Otto Dix, whose portraits feature similarly overdrawn wrinkles and aberrantly oversize hands.
According to the researchers, the study makes clear that early-stage neurons can overcome inhibitors present in the adult nervous system that normally work to maintain the elaborate central nervous system and to keep cells in the adult CNS from growing aberrantly.