We obtained spectral interactions between Roundup or glyphosate and the active site
of the purified cytochrome P450 aromatase by measuring the absorbance of the preparations from 375 to 475 nm.
The research team created a peptide with an alpha-helical shape that would fit into the active site
of the calpain protease.
The initial steps of polymerization are characterized by active site
exposition and fast pore filling by monomer.
Such resistance arises when a viral strain mutates to change the structure of a pocket, eliminating the ability of a drug to bind and block the active site
The research shows that the active site
of the endonuclease is shaped like a cave with two metal ions at the bottom.
Although we cannot state with certainty the mechanism by which Cd(II), Fe(II), or Pb(II) [three metals that have divergent coordination chemistries and different ligand preferences (Lippard and Berg 1994)] inactivates Ape1, both X-ray crystallography and NMR spectroscopy studies found that lead can occupy two potential divalent metal binding site within the Ape I active site
(Beernink et al 2001; Lowry et al.
By creating tiny cavities in a polymer, or plastic, that mimic the active sites
of enzymes, the team essentially produces artificial enzymes, or "plastizymes," as Mosbach calls them.
The fingers close around the active site
of the enzyme, and that allows important residues to catalyze the incorporation of a nucleotide.
To date, all known HIV protease inhibitors act by binding to the active site
of the enzyme.
Neose's GlycoPEGylation(TM) technology can extend and customize protein half-life by uniquely linking various size polyethylene glycol (PEG) polymers to glycans that are remote from the protein's active site
, thereby preserving activity.
Understanding the cooperation of the active site
and its environment in tuning the acidity of the system is a fundamental chemical problem," says Joachim Sauer, a chemist at Germany's Humboldt University in Berlin.
Hirudin is two-headed and can attach itself to both the active site
of thrombin, as well as to another site that is specific to thrombin.