remodeling

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Airway remodeling occurs in patients in whom asthma is not adequately controlled over a long period of time.
Despite its established pro-inflammatory actions on COPD, the action of PAF on airway remodeling has been still unclear.
Nor was there a difference in postbronchodilator forced expiratory volume, demonstrating that regular ICS did not significantly affect airway remodeling.
A comparison of terminal airway remodeling in chronic daily versus episodic ozone exposure.
START also provided evidence that budesonide may modify the long-term process of airway remodeling that is believed to be associated with asthma exacerbations.
SLPI also impacts mast cell chymase and tryptase, and thrombin, each of which may be involved in airway remodeling in asthma.
Additionally, as we expand our body of knowledge about IL-9's role in mast cell regulation, airway remodeling, and other functions involved in the onset of asthma symptoms, we believe these preclinical data provide further support for IL-9 inhibition as a potential therapeutic approach to treating patients with moderate to severe asthma.
Chronic, repeated inflammatory challenge of the airways may result in airway remodeling that leads to irreversible lung disease.
TOPIGEN's other COPD program, PD3, is an aerosolized phosphodiesterase inhibitor being developed to target multiple gene-expression pathways linked to the progressive airway remodeling associated with COPD.
We conclude that PM penetrates into and is retained in the walls of small airways, and that, even in nonsmokers, long-term exposure to high levels of ambient particulate pollutants is associated with small airway remodeling.
Delivered via aerosol, PD-3 is designed to inhibit several gene expression pathways linked to the progressive airway remodeling associated with COPD.
Delivered via aerosol, the product (PD-3) is designed to inhibit gene expression pathways linked to the progressive airway remodeling associated with the disease.

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