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Alkylating agents work by inducing changes in DNA molecules that lead to the death of the cancer cell.
The survivors reported their children's health problems through questionnaires, and investigators also examined medical records from survivors and their children, focusing on survivors' history of radiation to the testes or ovaries and chemotherapy with alkylating agents.
For caregivers and their patients, the therapeutic area that is at the forefront of attempts to mitigate exposure to cytotoxic drugs is clinical oncology, a field that continues to rely heavily on antineoplastics, a class that includes alkylating agents and antimetabolites, to treat a wide range of cancers.
He is currently developing a high-throughput worm genome-wide microarray to screen compounds and develop signature profiles of response to a variety of toxicants, including bacterial toxins, chemicals, metals, and alkylating agents.
2] Leoni LM et al, Bendamustine (Treanda) Displays a Distinct Pattern of Cytotoxicity and Unique Mechanistic Features Compared with Other Alkylating Agents.
Because cell biology studies indicate that many metal compounds enhance the genotoxic effects of known mutagens such as ultraviolet C radiation, X rays, benzo[a]pyrene, cisplatin, and DNA alkylating agents, it has been postulated that environmental metals are comutagenic and potentiate the carcinogenic effects of DNA-damaging agents by inhibiting DNA repair processes (Hartwig et al.
Patients who received polyfunctional alkylating agents such as cyclophosphamide and cisplatin developed no restenosis, as did those who received anthracycline antibiotics such as doxorubicin and bleomycin and those who got plant alkaloids such as vincristine, vinblastine, and paclitaxel.
very good results were obtained with cis-platin from the platinum group of alkylating agents.
It induces apoptosis (cell suicide) due to its p53 dependent alkylating activity but with a more pronounced and longer lasting DNA damaging effect compared to other alkylating agents.
1] (which is secreted by mold that grows on grains and is associated with liver cancer) as well as environmental alkylating agents in various cell types, including liver cells.
lymphocytic leukemia in people who have been treated with alkylating agents and have, failed treatment with fiudarabine.
The study involved drugs called alkylating agents that are widely used to treat a variety of pediatric cancers.