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This model suggested that SULT1E1 could bind two molecules of estradiol per molecule of enzyme, one at a preferred site for sulfonation and the other at an allosteric site associated with substrate inhibition (Zhang et al.
In its lead inflammation program, Locus has created exquisitely selective p38 inhibitors which bind to p38 at an allosteric site and do not involve the ATP site.
Allosteric sites may offer an improved safety profile over ATP site inhibitors as well as provide a dual mode of action.
 
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