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In contrast, these same PCBs antagonized SXR, blocking the expression of target genes and inhibiting the human body's ability to physiologically counteract harmful effects of exposure (several less stable PCBs did not antagonize SXR, however).
Greenwalt and department management have deceived the public, mismanaged department funds and antagonized people and organizations who are working to help.
They antagonized advocates, AARP got involved, the legislature created an oversight committee, and the backlash generated SB 190," says Jim Lehrman, deputy commissioner for Long Term Care Regulatory, Department of Human Services (DHS).
In the course of announcing, explaining, and exemplifying the coming reign of God, Jesus antagonized all the powerful social groups who saw no need for any changes that might have an impact on their roles.
Covering the same ground in her 1989 autobiography, Holding On to the Air, she had antagonized some reviewers for discussing Balanchine in a manner they had found arrogant, and even a bit brattish.
This approach impedes growth and development of the institution, creates dissension among the medical staff when members not involved feel antagonized and/or ignored, and excludes majority input.
Gli expression levels are important in identifying potential Hedgehog pathway targeted drug candidates since Gli levels are higher when the Hedgehog pathway is turned on, or agonized, and lower when Hedgehog signaling is inhibited, or antagonized.