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Related to antigen-binding site: variable region, Surface immunoglobulin
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Phage display, using combinatorial peptide libraries, is a relatively straightforward method for identifying suitable peptides for binding to the antigen-binding site of mAbs (27).
Some of these synthetic molecules recognize the antigen-binding sites of disease-specific antibodies well enough to pull them from blood samples, although they almost certainly don't bind as well as the native antigens.
Most students fail to really understand the concept and appreciate the cooperative binding of multiple antigen-binding sites.

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