It is unclear if the defect is primarily a T-cell aberration or if it is due to an antigen-presenting cell
Activation of cutaneous immunity by percutaneous absorption of chemical through the stratum corneum is well established; however, given the long dissolution half-life for beryllium metal and its alloys, we hypothesized that beryllium particles would have to colocalize with the cutaneous antigen-presenting cell
in the epidermis in order to activate a cell-mediated immune response.
Ley said antigen-presenting cells
take up infectious organisms, foreign materials and self-proteins (in the case of autoimmune diseases) and "chop them into little pieces called epitopes" and then display the pieces on the surface of the cell.
Chakraborty, a chemical engineer and biochemist by training, became interested in immunology after hearing about a paper on the immunological synapse, a crucial communications point for T cells and antigen-presenting cells
Treatment with autologous antigen-presenting cells
activated with the HER-2 based antigen Lapuleucel-T: results of a phase I study in immunologic and clinical activity in HER-2 overexpressing breast cancer
Also an activation of antigen-presenting cells
, NK-cells and T-cells is obvious, and a release of different cytokines may be responsible for the various beneficial clinical effects but also the--although rarely observed--adverse reactions during this kind of therapy.
This needle-free technology uses a patch placed on the surface of the skin to deliver vaccines and adjuvants via a group of antigen-presenting cells
in the skin (Langerhans cells) to the nearby lymph nodes to produce a sustained immune response.
The influenza vaccine patch uses Iomai's proprietary transcutaneous immunization technology, which delivers vaccine to a group of antigen-presenting cells
in the skin called Langerhans cells.
Iomai's TCI technology uses a patch applied to the skin like a bandage and worn for several hours to deliver vaccine and/or adjuvants to a group of antigen-presenting cells
(called Langerhans cells) in the skin called that carry the vaccine to the nearby lymph nodes where they prompt a sustained immune response.
The vaccine is an autologous cellular product composed of antigen-presenting cells
enriched from peripheral blood mononuclear cells obtained via leukapheresis.
The Ii protein normally blocks the antigenic peptide binding site of MHC Class II molecules at time of synthesis in the endoplasmic reticulum of antigen-presenting cells