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Related to attenuated virus: parainfluenza virus, Simian immunodeficiency virus, live attenuated vaccine
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March 24, 2011 /PRNewswire-USNewswire/ -- The Food and Drug Administration (FDA) today approved the use of Zostavax, a live attenuated virus vaccine, for the prevention of shingles in individuals 50 to 59 years of age.
But clinical trial testing of the inactivated and live attenuated virus vaccines already is underway, and programs for distributing the vaccines and conducting surveillance should be in place when the vaccines are ready, the officials said.
The recommendations also specify that health care personnel can receive either a trivalent inactivated influenza virus vaccine or a live, attenuated virus vaccine.
Replacement of the NS1 gene of WSN virus with that of the 1918 virus resulted in an attenuated virus in mice, but this virus more efficiently inhibited the IFN[alpha]/[beta] system in human cells (21,29).
What's more, the work "fortifies the idea that you can have an attenuated virus in an individual without causing disease.
Live, attenuated virus vaccines being developed by potential competitors have a small, but real risk of causing severe, encephalitic West Nile disease.
The new method is called Synthetic Attenuated Virus Engineering (SAVE).
It is made from noninfectious particles, not live or attenuated virus.
Although these vaccines can cause infections of the embryo or fetus, and pregnant women should be informed of the presence of live organisms if they are given a live attenuated virus vaccine, there is no convincing evidence that any vaccine, bacterial or viral, has caused fetal or embryonic harm.
Since a live, attenuated virus vaccine based on the AA ca donor virus has been licensed by the Food and Drug Administration for general use in healthy persons 5-49 years of age, the infrastructure for manufacture and characterization of live, attenuated virus vaccines exists.
I think it lends more credence to a live, attenuated virus," acknowledges Anthony S.