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virus |
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| Through the company's research and development work, Baxter has been successful in growing wild-type virus in its vero-cell culture, which means that the company could begin vaccine production without having to wait for high-growth or attenuated virus reassortants normally used when vaccine is produced in eggs. Replacement of the NS1 gene of WSN virus with that of the 1918 virus resulted in an attenuated virus in mice, but this virus more efficiently inhibited the IFN[alpha]/[beta] system in human cells (21,29). Researchers have documented some of these risks, including the possibility of enhanced replication of the attenuated virus in individuals with compromised immune systems, and the possibility of bacterial superinfection (a reinfection or second infection) if the replicating live virus disrupts nasal membranes. |
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