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Of all the complications of autonomic neuropathy, the most dangerous is cardiac autonomic neuropathy, which causes damage to the autonomic nerve fibers in the heart and blood vessels, resulting in abnormalities in heart rate control and vascular dynamics.
Autonomic nerve fibers, which innervate smooth muscle of the vertebrate intestine, do not always terminate with morphologically distinct neuromuscular synapses (Janig, 1978).

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