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virulence |
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Interest in a potential attenuated live vaccine has been stimulated by the finding that targeted disruption of the Blastomyces dermatitidis gene, which encodes the surface adhesin BAD-l, renders the mutant avirulent. Its two major subspecies (biovariants) are F tularensis biovar tularensis (type A), the more virulent form that is most common in North America, and F tularensis biovar palaearctica (type B), a relatively avirulent form that is found in Europe and Asia. and I are studying these long-term survivors to ascertain whether something unusual about their immune systems explains their response or whether they carry an avirulent strain of the virus. |
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