Al-Zoubi and his team at Stem Cells of Arabia developed a novel way to purify specific types of stem cells taken from a diabetic patient's blood that are able to differentiate into Beta cells
that secrete insulin when transplanted into pancreatic tissues.
This defect impairs beta cell
ability to respond to increasing demand caused by insulin resistance as it progresses.
The team could see new beta cells
were trying to form in blood samples, which they can now learn from.
In type 1 diabetes, the immune system attacks and destroys the insulin-producing beta cells
in the pancreas.
Transplantation of the pancreas or insulin-producing beta cells
offers the best hope of cure for people with IDDM.
Gastrin-based Approaches for beta Cell
In this proposed model of T1D, the loss of beta cell
function may not be driven by beta cell
death, as is widely believed, but rather by the regression of beta cells
into a less mature state in which they are no longer able to produce insulin effectively, or at all.
We believe that a single short course of otelixizumab may have the potential to preserve residual beta cell
function and offer people with autoimmune type 1 diabetes improved disease control" said Dr.
Tests in mice have shown the mix of three drugs and an antiin-flammatory enzyme renews insulin-producing beta cells
Patent and Trademark Office indicated its intent to grant a patent for the use of Lisofylline (LSF) to restore insulin-producing beta cell
mass and function in people with diabetes.
The SIK2-p35-PJA2 pathway provides us with new targets to try and improve beta cell
functionality to prevent and treat Type 2 diabetes," he added.
In Phase 2 trial, TOL-3021 Increased Pancreatic Beta Cell
Function and Reduced Disease-Specific T-Cell Activity in Patients with Type 1 Diabetes--