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Viral particles bind specifically to digestive ducts (midgut, main and secondary ducts, and tubules) by carbohydrate structures with a terminal N-acetylgalactosamine residue in an [alpha] linkage (same binding site used for recognition of human histo-blood group antigens).
This result indicated that the common binding site was a nonclassical membrane estrogen receptor.
On human chromosome 2, RUNX1 fits into a binding site that lies in the middle of a gene called programmed cell death 1, or PDCD1.
 
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