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barrier |
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barrier noun bar, barricade, bound, boundary, check, confines, enclosure, encumbrance, fence, hindrance, hurdle, impediment, interference, limit, obstacle, obstruction, partition, prevention, preventive, protective device, rampart, restraining device, restriction, safeguard, stay, stop, stumbling block, termination, wall See also: bar, bulwark, check, complication, damper, deterrence, deterrent, enclosure, estoppel, handicap, hindrance, impediment, limitation, mete, obstacle, obstruction, panoply, predicament, prohibition How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Blood-Brain Barrier (BBB) research embodies the true meaning of a "translational model" of neuroscience wherein breakthroughs in basic neuroscience are delivered to the clinic and require an agent delivery strategy and/or the ability to target specific areas of the brain. Long recognized as "the A in ADME", pION has commercialized PAMPA and developed applications that are highly correlated with Caco-2, gastrointestinal tract (GIT) and blood-brain barrier (BBB) permeation. Two accessory mechanisms are also suggested to be involved in MCS, one involving nitric oxide and the other peroxynitrite:nitric oxide inhibition of cytochrome P450 activity and peroxynitrite-mediated increased permeability of the blood-brain barrier (BBB) (Pall 2002b; Pall and Satterlee 2001). |
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