After Shane underwent intensive chemotherapy to kill off his own bone marrow cells
, 30% of Jaydon's bone marrow was transplanted at Alder Hey Children's Hospital in Liverpool in August 2010.
Dr Helmut Drexler, from the University of Freiburg, who led the research, said, 'Our results lend support to the concept that autologous (patient's own) bone marrow cells
can be used to enhance left-ventricular functional recovery in patients after acute myocardial infarction (heart attack).
Chemotherapy killed off his own bone marrow cells
and Jaydon was then brought to the hospital, with 30% of his bone marrow transplanted into Shane.
The researchers used retroviral insertion site analysis to determine which type of bone marrow cell
from mice could give rise to bone-producing cells when transplanted into recipient mice.
The Heeschen study demonstrates that the Harvest BMAC System is, in fact, capable of producing a bone marrow cell
composition that is equal to, and may in fact be clinically superior to, the cell composition prepared by the gold standard.
Therefore, the ability to produce clinical quantities of these cells from a much smaller starting sample, the basis of Aastrom's proprietary technology, is intended to provide a therapeutic substitute for medical applications that are treatable with large volumes of bone marrow cells
Left ventricular function and exercise capacity increased, while the area of the heart muscle damaged shrank, in 18 patients given infusions of their own bone marrow cells
up to eight years after a heart attack, according to a new study.
They also found bone marrow transplantation experiments indicated that A2bAR bone marrow cell
signals alone were not sufficient to elicit this effect.
The researchers are conducting further studies to evaluate bone marrow cell
and extract therapies in order to identify the proteins and factors within the extract and gain insight into the possible mechanisms of cardiac functional improvement.
Tests show that a rodent bone marrow cell
similar to one found in people acts as a multipurpose stem cell, much as embryonic stem cells do.
A specific type of bone marrow cell
may have the capability of developing into a functioning liver cell, a finding that may have important implications for the treatment of patients with advanced liver disease.
The combination of Ig-GAD2 and bone marrow cells
did result in production of new beta cells, but not in the way we expected," Zaghouani said.