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Related to capillary loops: free nerve endings
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Diffuse lesions are composed of a widespread increase in eosinophilic material within the mesangium, which stains positive with periodic acid-Schiff (PAS), and uniform widening of the capillary loops.
As you age, the outermost layer of your skin begins to suffer from a loss of vertical capillary loops that supply much-needed oxygen and nutrients to the skin.
Endothelial tubes begin to form, homing in toward the tumor with the formation of capillary loops.