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Related to caseous necrosis: granuloma, tuberculosis, Fibrinoid necrosis
See: death, demise
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11] The TB abscess was described as degenerate caseous necrosis and/or liquefied necrotic material with marked degenerating and viable inflammatory cell infiltration without epithelioid granuloma.
Confirmatory diagnosis was made by biopsy and histopathology in all cases reported in literature with typical granulomatous lesion with caseous necrosis surrounded by epithelioid and Langhans-type giant cells.
The prostate tissue biopsy showed granulomatous inflammation and focal necrosis; no AFB were seen and caseous necrosis was not noted.
In disseminated tuberculosis, foci of specific lesions (granulomas) comprised large central zones of caseous necrosis surrounded by a few inflammatory cells.
Further, extensive caseous necrosis along with liquefaction of the caseous material with cavity formation has also been reported (59,62-66).
In case 2, the two-year persisting caseous necrosis could have been due to a reinfection partially controlled by rifampicine.
All cases fulfilled the clinical criteria according to Chinese Society of Gastroenterology :[sup][5] (1) histological biopsy showed epithelioid granuloma with caseous necrosis in intestinal tissue or mesenteric lymph nodes; (2) intestinal tissue biopsy was positive for MTB on culture or acid-fast stain; (3) patients showed a good response to anti-TB therapy with clinical manifestation consistent with active TB.
granulomatous lymphadenitis (showed only epithelioid granulomas without caseous necrosis), necrotizing lymphadenitis (showed caseous necrosis only without epithelioid granulomas), and necrotizing suppurative lymphadenitis (showed plenty of polymorphs, necrotic debris with or without epithelioid granulomas).
The classical picture of histopathology of the lymph nodes is a granulomatous lesion with caseous necrosis and numerous epitheloid cells, lymphocytes, plasma cells, and fibroblasts and Langerhans type of multinucleated giant cells.
Central non-enhancing areas in the nodes reflect caseous necrosis.