The scientists note that some cancers, such as breast and prostate cancer, were not included in the report because of their inability to find reliable stem cell division
rates in the scientific literature.
According to a press release, orientation of cell division
is a very important process both for proper development of embryonic tissues and organs as well as for the maintenance of tissues and organs in adults.
My current research focuses on genes that are molecular switches for cell division
and I am trying to understand how cell division
controls growth and development in plants.
Furthermore, mutant genes that cause inherited Alzheimer's disease cause the same defect in chromosome segregation as does cholesterol, thus indicating the presence of a common cell division
problem in both familial and 'sporadic' (non-familial) Alzheimer's disease.
Researchers found that depleting SIK2 from ovarian cancers sensitized the cancer cells to paclitaxel, a commonly prescribed chemotherapeutic agent that inhibits cell division
, making the drug more effective in stopping the cancer's growth.
The findings are important because it explains how CDK2 normally shrugs off p27 and how some abnormal enzymes cause this to occur prematurely, putting cell division
into overdrive-a state that produces cancer, said Richard Kriwacki, Ph.
Lead researcher Professor Andrew Sharrocks, of Manchester University, said: "Enzymes are proteins that speed up or 'catalyse' the body's chemical reactions such as those required for normal cell division
occurs millions of times each day in the human body.
The target of the drug is Plk-1 (polo-like kinase1), a protein that acts as a catalyst in cell division
Professor Premkumar Reddy, from Temple University School of Medicine in Philadelphia, USA, who led the research, said: 'Because all signalling pathways that have gone awry in a cancer cell ultimately affect cell proliferation, a reasonable approach to cancer therapy is to develop inhibitors that block the function of a critical molecule required by a tumour cell to complete cell division
The authors of this study found a way - by inserting a gene called hTERT - to shut off a portion of one of the enzymes involved in the process of cell division
Drug-induced arrest of cell division
has long been considered only a stop-gap measure, because it was presumed the cells would eventually repair their damage and go on to divide again after treatment," explains Igor Roninson, professor of molecular genetics.