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This potentially affects the survival of T cells, limits the ability of lymph nodes to support healthy T cell homeostasis and has been associated with reductions in the size of total and naive CD4+ T cell populations [4,33].
CD20 targeted B cell depletion also effectively normalizes the significant disturbances in peripheral B cell homeostasis discussed earlier, including naive lymphopenia, plasma cell expansions, and the expansion of autoreactive 9G4 memory B cells.
Viability and cytotoxicity assays are routinely used to determine how various treatments potentially perturb cell homeostasis leading to decreased viability and increased cytotoxicity.
My group has challenged this view and used a systems biology approach to discover that the lysosome is subject to a global transcriptional regulation, is able to adapt to environmental clues, and acts as a signalling hub to regulate cell homeostasis.
Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis," Cell Stem Cell, July 2016 DOI: 10.