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This potentially affects the survival of T cells, limits the ability of lymph nodes to support healthy T cell homeostasis and has been associated with reductions in the size of total and naive CD4+ T cell populations [4,33].
CD20 targeted B cell depletion also effectively normalizes the significant disturbances in peripheral B cell homeostasis discussed earlier, including naive lymphopenia, plasma cell expansions, and the expansion of autoreactive 9G4 memory B cells.
Finally, a French study examined the impairment of interleukin-2 synthesis by naive CD4 T cells and alteration of TNF alpha T cell homeostasis by memory CD8 T cells under HAART and found a positive correlation with lipodystrophy (Abstract 391).