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necrosis |
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l,7) Infiltration of the surface epithelium may give the tumor an ulcerated appearance, but central necrosis is rare. The mediastinal lymph nodes were also strongly positive, accompanied by central necrosis. In addition, intravital microscopy using a murine pseudo-orthotopic breast cancer model showed that NPI-2358 induces a rapid decrease in tumor blood flow resulting in tumor vascular collapse and central necrosis in established tumors. |
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