Mechanisms of DNA doublestrand repair and their potential to induce chromosomal aberrations
The chromosomal abnormalities frequency was improved with the combination of GTG-banding FISH techniques and FISH has an advantage in detection of detecting aneuploidy and deletions of common chromosomal aberrations
An increase in the frequency of chromosomal aberrations
in peripheral blood lymphocytes is associated with an increased overall risk of cancer [11,10].
and chromium blood levels in relation to polymorphisms of GSTM1, GSTTl and GSTP1 genes in welders.
Moreover, recent cytogenetic studies have identified that some specific chromosomal aberrations
may be strongly associated with the oligodendroglioma prognosis and treatment response.
frequency in lymphocytes predicts the risk of cancer: result from a pooled cohort study of 22,358 subjects in 11 countries.
in lymphocytes of healthy subjects and risk of cancer.
Methods used to evaluate exposed individuals include chromosomal aberration
(CA) analysis, which is considered a reliable test because of the association between the frequency of CAs and the risk of developing cancer (Bonassi et al.
The following tests for mutagenic potential were negative: (1) in vivo (mouse) cytogenetic assay; (2) in vitro chromosomal aberration
assay; (3) alkaline elution assay; (4) V-79 assay; and (5) Ames test.
today announced results of a new study that found Chromax(R) chromium picolinate does not produce chromosomal aberrations
in Chinese Hamster Ovary (CHO) cells.
3,4] However, other chromosomal aberrations
have been described.
14] However, the scarcity of reported cytogenetic abnormalities in benign thymic tumors poses difficulties in determining significance of the observed chromosomal aberrations
and in correlating cellular morphologic findings with cytogenetic findings.