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arm |
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The mean values and standard deviations of relative length and centromeric index were estimated from chromosome arm lengths. Since the rare progeny will be heterozygous for the mutagenized chromosome arm, they are used to isolate a stock of the putative meiotic mutant through a subsequent series of crosses. The paradigm of heritable CRC is familial adenomatous polyposis coli (APC), in which mutations of the APC gene on chromosome arm 5q cause the development of many of the polyps found in patients under the age of 30. |
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