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cleavable |
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The acquisition of a highly cleavable HA converted an avirulent strain to virulence in Pennsylvania in 1983 (H5N2), Mexico in 1994 (H5N2), Italy in 1997 (H7N1), Chile in 2002 (H7N3), and Canada in 2004 (H7N3) (Table). SGN-35 is an ADC comprised of an anti-CD30 antibody joined by an enzyme cleavable linker to a potent, synthetic drug payload, monomethyl auristatin E (MMAE), using Seattle Genetics' proprietary technology. SGN-35 is an ADC comprised of an anti-CD30 antibody linked by an enzyme cleavable peptide linker to an auristatin derivative, monomethyl auristatin E (MMAE), using Seattle Genetics' proprietary ADC technology. |
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