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cleavage
(redirected from cleavage site)

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University of California (Oakland, CA) has patented an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site of human CD154, and a second nucleotide sequence encoding an extracellular subdomain of human CD154 that binds to a human CD154 receptor.
Maturation of the precursor proteins begins by intramolecular cleavage of Gag-Pro-Pol and continues by a process of ordered cleavages governed by differences in the inherent processing rates at each cleavage site (see Figure 3) [14-18] which for HIV Gag can vary up to 400-fold [16,17].
 
 
 
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