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Related to coagulation pathways: Extrinsic pathway, Clotting cascade
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Inappropriate activation of the coagulation pathways, however, can promote intravascular thrombosis (Chu 2006; Mackman 2005).
Although a known response to perfluorocarbon-based emulsion products is the transient decline in circulating platelet counts, the mechanism by which this phenomenon occurs is poorly understood and its impact on overall coagulation pathways and clinical outcomes remains the subject of debate.
Tobacco smoke--including secondhand smoke--activates blood coagulation pathways that could lead to coronary thrombosis, or heart attack.