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To analyze these proteins, they must be physically separated into discrete pools using different separation technologies (two-dimensional gel electrophoresis, column chromatography and others). Traditional column chromatography systems used to purify biopharmaceuticals require significant downtime and labor to disassemble components for routine maintenance, resulting in lost throughput. Sellick demonstrated the higher binding capacity of single-use Mustang(TM) membrane capsules for large molecule applications compared to conventional resin- or gel-based column chromatography. |
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