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Chiral biphenyl dopants, conformationally restricted (1-8) and unrestricted (9-19) biphenyl core were investigated by using DFT studies, the computed data of dipole moment () and dihedral angle between two phenyl rings (Fig.
Using recombinant DNA technology, the L1 protein is expressed in Saccharomyces cerevisiae (yeast), and the proteins self-assemble into conformationally intact, noninfectious VLPs.
1991), indicate that pseudoautosomal heterochromatin is conformationally and compositionally distinct from autosomal heterochromatin within the same genome.
Then we can make a molecule that has all of the features important for biological activity, but is conformationally constrained so it can't rotate or do anything else but look like the conformation that's recognized by the receptor or enzyme," Gadek continues.
The PTrMA with DP = 50 is conformationally very stable even at rather high temperatures in solution and did not show any change in optical activity when heated at 60[degrees]C in THF, and the poly(D2PyMA) with DP = 80 was also conformationally stable mainly due to association of the polymer chains.
We proposed the preparation of a novel and diverse library of conformationally constrained peptidomimetics containing quaternary stereocenters derived from B/C/P approach with increased biological relevance.
Dimers are believed to interact with the target RNA in bivalent fashion while the conformationally adoptable linkers may allow the scanning for multiple binding sites on the RNA.
Biotechnology company Marina Biotech Inc (OTC Markets:MRNA) revealed on Friday the execution of a licensing agreement for its Conformationally Restricted Nucleotide (CRN) technology for the development of both single- and double-stranded oligonucleotide therapeutics.
Comparison of the mechanism of induction of apoptosis in ovarian carcinoma cells by the conformationally restricted synthetic retinoids CD437 and 4-HPR.
For all [alpha]-chitin, such as the PG chitin used, the amide I band, which indicates in-plane NH bending combined with C = O stretching vibrations and CN stretching modes (55) is more conformationally sensitive than the amide II and III vibrations.
Design of a conformationally restricted analogue of the antiepilepsy drug vigabatrin that directs its mechanism of inactivation of [gamma]-aminobutyric acid aminotransferase.