9, 2012 /PRNewswire/ -- Sanofi (EURONEXT: SAN and NYSE: SNY)announced today new Phase II data showing that treatment with a novel, investigational, selective JAK2 inhibitor (SAR302503) reduced spleen size and improved constitutional symptoms
in patients with intermediate-2 or high-risk primary or secondary myelofibrosis (MF), a hematologic malignancy with unmet medical needs.
Her constitutional symptoms
had worsened over the previous year, and she had lost eight pounds.
This case was challenging because of the long duration, presence of constitutional symptoms
, recent ingestion of traditional medicament, shifting dullness and dullness in the flanks on clinical examination, previous non-significant rectal biopsy, ascites revealed on ultrasound examination, and unhelpful laboratory investigations.
Patients present with a systemic illness that manifests as disseminated lymph nodes, constitutional symptoms
The majority of subjects achieved a complete resolution or marked improvement of common constitutional symptoms
He had experienced constitutional symptoms
and general malaise for 2 months.
ulceration, leukoplakia, or erythroplakia), cervical lymphadenopathy, unilateral signs or symptoms, unexplained weight loss, constitutional symptoms
In those trials, the headache and mild constitutional symptoms
appear to occur mostly with the first dose of drug given and then wane with subsequent doses, Dr.
4) Constitutional symptoms
such as fever and malaise are often present, and circulating immune complexes have been identified in some patients.
After 48 hours, the patient became afebrile, and his constitutional symptoms
Clinical responses seen in 39 patients enrolled with ET included long-term reductions in elevated platelet and white blood cell counts, and, when present, splenomegaly and constitutional symptoms
He denied any bone pain or significant constitutional symptoms
, and his medical and family history was unremarkable.