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| The mutation leads to a loss of guanosine triphosphatase activity and thus to adenyl cyclase overactivity and subsequent overproduction of cyclic adenosine monophosphate (cAMP). Benowitz' team injected the animals' eyes with oncomodulin in slow-release capsules, along with a chemical called cyclic adenosine monophosphate that's known to prompt nerve cells to respond to other growth factors. David Summers, "at a certain dose the drug simply shuts down SMC migration by elevating cyclic adenosine monophosphate (cAMP) which modulates the G-protein pathway arresting cell migration by causing dose-response retraction of the cells microtubule pods. |
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